Abstract
The effects on Staphylococcus aureus viability and beta-lactamase activity of concentrations that simulated those in human serum after a combined dose of 875 mg of amoxicillin and 125 mg of clavulanic acid were studied in an in vitro pharmacodynamic model. Six hours of preexposure to concentrations of the amoxicillin-clavulanic acid combination that were higher than the amoxicillin-clavulanic acid MIC led to a reduction of the initial inoculum of >90% and to a significant decrease of beta-lactamase activity versus those of the control even from 6 h, when concentrations were subinhibitory. The postantibiotic effect and post-beta-lactamase inhibitor effect contributed to these results.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amoxicillin / blood
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Amoxicillin / pharmacology*
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Amoxicillin-Potassium Clavulanate Combination
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / pharmacology*
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Clavulanic Acid
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Clavulanic Acids / blood
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Clavulanic Acids / pharmacology*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Drug Therapy, Combination / blood
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Drug Therapy, Combination / pharmacology*
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Humans
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Kinetics
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Penicillins / blood
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Penicillins / pharmacology*
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Serum Bactericidal Test
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / enzymology
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Clavulanic Acids
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Penicillins
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Clavulanic Acid
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Amoxicillin-Potassium Clavulanate Combination
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Amoxicillin
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beta-Lactamases