The increasing burden of disease in Bangladeshi children due to Haemophilus influenzae type b meningitis

Ann Trop Paediatr. 1997 Mar;17(1):5-8. doi: 10.1080/02724936.1997.11747855.

Abstract

A laboratory-based study of diagnosed bacterial meningitis in the national paediatric hospital identified 852 cases of meningitis in the 8-year period 1987-1994. There were 587 culture-positive cases, of which Haemophilus influenzae (47%) and Streptococcus pneumoniae (32%) accounted for 80%. H. influenzae showed a remarkable increase of 700% during the study period. Most of the H. influenzae cases (90%) occurred in the 1st 2 years of life. Analysis of culture-negative specimens by antigen detection in the last 2 years also revealed the predominance of H. influenzae (71.4%) and S. pneumoniae (22.4%). Typing of H. influenzae isolates during this time showed that 98% of the strains were type b. This retrospective hospital-based study indicated a pronounced increase in the incidence of H. influenzae meningitis and strongly supports the need for large-scale Hib vaccination for young children. However, such nationwide intervention will probably need to be based on a prospective on a prospective and population-based surveillance of H. influenzae infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Bangladesh / epidemiology
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Infant, Newborn
  • Meningitis, Bacterial / cerebrospinal fluid
  • Meningitis, Bacterial / epidemiology*
  • Meningitis, Bacterial / microbiology
  • Meningitis, Haemophilus / cerebrospinal fluid
  • Meningitis, Haemophilus / microbiology
  • Meningitis, Meningococcal / cerebrospinal fluid
  • Meningitis, Meningococcal / microbiology
  • Pneumococcal Infections / cerebrospinal fluid
  • Pneumococcal Infections / microbiology
  • Retrospective Studies