Abstract
In a study evaluating naltrexone with either an intensive psychosocial protocol or standard community treatment for opioid dependence, 13 of 81 subjects overdosed within a 12-month period of study participation. There were four fatalities, one of which was a suicide. Among the nine nonfatal overdoses, there were four suicide attempts. Characteristics of subjects and naltrexone-taking are described.
Publication types
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Clinical Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Depressive Disorder / psychology
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Female
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Humans
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Male
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Naltrexone / adverse effects
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Naltrexone / therapeutic use*
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Narcotic Antagonists / adverse effects
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Narcotic Antagonists / therapeutic use*
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Narcotics / poisoning*
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Opioid-Related Disorders / drug therapy*
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Opioid-Related Disorders / mortality*
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Opioid-Related Disorders / psychology
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Psychiatric Status Rating Scales
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Psychotherapy
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Suicide, Attempted / psychology*
Substances
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Narcotic Antagonists
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Narcotics
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Naltrexone