PF1092A, B and C, new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum. I. Taxonomy of producing strain, fermentation, isolation and biological activities

J Antibiot (Tokyo). 1997 Apr;50(4):304-8. doi: 10.7164/antibiotics.50.304.

Abstract

Three new nonsteroidal progesterone receptor ligands, PF1092A, B and C, have been isolated from Penicillium oblatum. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies, and crystallization. All three ligands competitively inhibited [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 3.0 x 10 nM (PF1092A), 2.2 x 10(2) nM (PF1092B) and 2.2 x 10(3) nM (PF1092C).

MeSH terms

  • Animals
  • Binding, Competitive
  • Cytosol / metabolism
  • Fermentation
  • Furans / isolation & purification*
  • Furans / pharmacology
  • Ligands
  • Naphthols / isolation & purification*
  • Naphthols / pharmacology
  • Penicillium
  • Progesterone / metabolism
  • Receptors, Progesterone / drug effects*
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Swine

Substances

  • Furans
  • Ligands
  • Naphthols
  • PF 1092A
  • PF 1092B
  • PF 1092C
  • Receptors, Progesterone
  • Sesquiterpenes
  • Progesterone