The roles of excessive gastro-oesophageal reflux, disordered oesophageal motility and decreased mucosal sensitivity in the pathogenesis of Barrett's oesophagus

Eur J Gastroenterol Hepatol. 1997 May;9(5):515-9. doi: 10.1097/00042737-199705000-00019.

Abstract

Barrett's oesophagus is often considered an end stage of gastro-oesophageal reflux disease. In its pathogenesis increased oesophageal acid exposure, disturbed oesophageal motility and decreased oesophageal mucosal sensitivity are thought to be of importance. In this review the role of each of these factors will be discussed and an update of the recent literature will be given.

Publication types

  • Review

MeSH terms

  • Animals
  • Barrett Esophagus / etiology*
  • Barrett Esophagus / metabolism
  • Barrett Esophagus / physiopathology
  • Esophageal Motility Disorders / complications
  • Esophageal Motility Disorders / metabolism
  • Esophageal Motility Disorders / physiopathology
  • Gastric Acid / metabolism*
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / metabolism
  • Gastroesophageal Reflux / physiopathology
  • Humans
  • Hydrogen-Ion Concentration
  • Intestinal Mucosa / metabolism*
  • Intestinal Mucosa / pathology
  • Manometry