9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors

J Med Chem. 1997 Jun 6;40(12):1768-70. doi: 10.1021/jm960827x.
No abstract available

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Adenine / analogs & derivatives*
  • Adenine / chemical synthesis
  • Adenine / chemistry
  • Adenine / pharmacology
  • Adenosine Deaminase Inhibitors
  • Anticonvulsants
  • Cyclic AMP / pharmacology
  • Cyclic GMP / metabolism
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Isoenzymes / antagonists & inhibitors*
  • Muscle, Smooth, Vascular / enzymology
  • Purines / chemistry*
  • Purines / pharmacology*
  • Structure-Activity Relationship

Substances

  • 2-trifluoromethyl-9-(2-fluorophenylmethyl)-N-methyladenine
  • Adenosine Deaminase Inhibitors
  • Anticonvulsants
  • Enzyme Inhibitors
  • Isoenzymes
  • Purines
  • 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine
  • 9-(2-hydroxy-3-nonyl)adenine
  • Cyclic AMP
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic GMP
  • Adenine