Sertoli-Leydig cell tumour in an infertile patient after stimulated ovulation

Hum Reprod. 1997 May;12(5):1021-3. doi: 10.1093/humrep/12.5.1021.

Abstract

A 36 year-old infertile female developed a stage IV (FIGO) ovarian carcinoma consisting of a poorly differentiated Sertoli-Leydig cell tumour after receiving one course of ovulation induction with follicle stimulating hormone (FSH), human menopausal gonadotrophin (HMG) and human chorionic gonadotrophin (HCG) followed by gonadotrophin-releasing hormone analogue (GnRHa). The patient died of liver metastasis and hepatic failure 4 1/2 months after first diagnosis, despite aggressive treatment consisting of debulking surgery and aggressive adjuvant chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chorionic Gonadotropin / administration & dosage
  • Chorionic Gonadotropin / adverse effects
  • Drug Therapy, Combination
  • Fatal Outcome
  • Female
  • Follicle Stimulating Hormone / administration & dosage
  • Follicle Stimulating Hormone / adverse effects
  • Gonadotropin-Releasing Hormone / administration & dosage
  • Gonadotropin-Releasing Hormone / adverse effects
  • Humans
  • Infertility, Female / therapy*
  • Liver Failure / etiology
  • Liver Neoplasms / complications
  • Liver Neoplasms / secondary*
  • Menotropins / administration & dosage
  • Menotropins / adverse effects
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / pathology
  • Ovulation Induction / adverse effects*
  • Sertoli-Leydig Cell Tumor / diagnosis*
  • Sertoli-Leydig Cell Tumor / pathology

Substances

  • Chorionic Gonadotropin
  • Gonadotropin-Releasing Hormone
  • Menotropins
  • Follicle Stimulating Hormone