Simvastatin-induced myopathy in a patient treated for hypercholesterolemia. Morphological aspects

E Wicher-Muniak; K Zmudka; W Dabroś; D Dudek; J Stachura

Simvastatin-induced myopathy in a patient treated for hypercholesterolemia. Morphological aspects

Pol J Pathol. 1997;48(1):69-74.

Authors

E Wicher-Muniak¹, K Zmudka, W Dabroś, D Dudek, J Stachura

Affiliation

¹ Department of Clinical and Experimental Pathomorphology, Jagiellonian University Medical College, Kraków.

PMID: 9200964

Abstract

Functional and histological changes in skeletal muscle developing during hypolipemic therapy, especially with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are rare. This paper reports a case of simvastatin-induced myopathy confirmed histopathologically and ultrastructurally.

Publication types

Case Reports

MeSH terms

Humans
Hypercholesterolemia / drug therapy*
Lovastatin / adverse effects
Lovastatin / analogs & derivatives*
Male
Middle Aged
Muscle, Skeletal / drug effects
Muscle, Skeletal / pathology
Muscle, Skeletal / ultrastructure
Muscular Diseases / chemically induced*
Muscular Diseases / pathology*
Simvastatin

Substances

Lovastatin
Simvastatin