Abstract
Mouse mammary tumor virus (MMTV) causes mammary carcinomas and T-cell tumors in mice. MMTV variants that induce T-cell tumors have a large deletion within the U3 region of the long terminal repeat (LTR) compared to MMTV strains that induce mammary tumors. We provide evidence here that T-cell tropic MMTV strains lack a redundant binding site for a cellular protein called NBP (negative regulatory element binding protein). The lack of NBP-binding sites in T-cell tropic MMTV strains presumably leads to higher levels of transcription in T-cells during the MMTV life cycle and an increased incidence of mutagenic integration events.
MeSH terms
-
Animals
-
Base Sequence
-
Binding Sites
-
DNA-Binding Proteins / metabolism
-
Female
-
Lymphoma, T-Cell / immunology*
-
Lymphoma, T-Cell / virology*
-
Mammary Neoplasms, Experimental / immunology
-
Mammary Neoplasms, Experimental / virology
-
Mammary Tumor Virus, Mouse / genetics
-
Mammary Tumor Virus, Mouse / immunology*
-
Mice
-
Mice, Inbred C3H
-
Nuclear Proteins / metabolism
-
Recombinant Proteins / biosynthesis
-
Repetitive Sequences, Nucleic Acid
-
Retroviridae Infections / immunology*
-
Sequence Deletion
-
Transcription Factors / metabolism*
-
Transcription, Genetic
-
Transfection
-
Tumor Virus Infections / immunology*
Substances
-
DNA-Binding Proteins
-
Nuclear Proteins
-
Recombinant Proteins
-
Son protein, mouse
-
Transcription Factors