Calcification, as a feature of the vasculopathy, is a common pathological finding in children with acquired immunodeficiency syndrome. Large and small blood vessels of many organs including brain, heart, lungs, kidneys, liver, and spleen are affected. We report a case with calcification in multiple organs that was most prominent in the cardiac and skeletal muscle cells and the blood vessels of the cerebrum. To our knowledge, calcification of this degree has not been documented previously in a human immunodeficiency virus-infected child.