In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines

Antisense Nucleic Acid Drug Dev. 1997 Jun;7(3):245-9. doi: 10.1089/oli.1.1997.7.245.
No abstract available

MeSH terms

  • Animals
  • Base Sequence
  • Drug Stability
  • Feces / chemistry
  • Guanosine
  • Male
  • Metabolic Clearance Rate
  • Oligonucleotides, Antisense / blood
  • Oligonucleotides, Antisense / chemistry
  • Oligonucleotides, Antisense / pharmacokinetics*
  • Oligonucleotides, Antisense / urine
  • Rats
  • Rats, Sprague-Dawley
  • Thionucleotides / blood
  • Thionucleotides / chemistry
  • Thionucleotides / pharmacokinetics*
  • Thionucleotides / urine
  • Tissue Distribution

Substances

  • Oligonucleotides, Antisense
  • Thionucleotides
  • Guanosine