Atypical eumycetoma caused by Phialophora parasitica successfully treated with itraconazole and flucytosine

S V Hood; C B Moore; J S Cheesbrough; A Mene; D W Denning

Atypical eumycetoma caused by Phialophora parasitica successfully treated with itraconazole and flucytosine

Br J Dermatol. 1997 Jun;136(6):953-6.

Authors

S V Hood¹, C B Moore, J S Cheesbrough, A Mene, D W Denning

Affiliation

¹ Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, UK.

PMID: 9217835

Abstract

Phialophora species are occasional pathogens causing subcutaneous and invasive disease. We report the first case of eumycetoma caused by P. parasitica in an otherwise healthy U.K. resident who visited India. She failed to respond to surgical excision and itraconazole, 400 mg daily, but responded to itraconazole, 400 mg daily, and flucytosine, 1 g three times daily, for 12 months. In vitro susceptibility testing predicted a response.

Publication types

Case Reports

MeSH terms

Adult
Antifungal Agents / therapeutic use*
Drug Therapy, Combination
Female
Flucytosine / therapeutic use
Foot Diseases / drug therapy
Foot Diseases / microbiology*
Humans
Itraconazole / therapeutic use
Microbial Sensitivity Tests
Mycoses / drug therapy*
Mycoses / microbiology*
Phialophora* / drug effects
Soft Tissue Infections / drug therapy
Soft Tissue Infections / microbiology*

Substances

Antifungal Agents
Itraconazole
Flucytosine