Abstract
Mutations in the presenilin 1 gene account for many cases of early onset familial Alzheimer's disease. Homozygosity for the 'T' allele of a polymorphism in the presenilin 1 gene has previously been reported to double the risk for Alzheimer's disease in a late onset Caucasian sample. Here we report that this polymorphism does not incur risk in a case control sample of early onset Alzheimer's disease, possibly suggesting a different disease etiology between the early and late onset forms.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Age of Onset
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Aged
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Alleles
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics*
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Alzheimer Disease / psychology
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Apolipoprotein E4
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Apolipoproteins E / genetics
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Apolipoproteins E / metabolism
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DNA / analysis
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Female
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Genotype
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Humans
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Male
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Membrane Proteins / genetics*
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Middle Aged
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Polymorphism, Genetic / physiology*
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Presenilin-1
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Risk
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Scotland / epidemiology
Substances
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Apolipoprotein E4
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Apolipoproteins E
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Membrane Proteins
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PSEN1 protein, human
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Presenilin-1
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DNA