Fetal bradycardia and uterine hyperactivity following subarachnoid administration of fentanyl during labor

Reg Anesth. 1997 Jul-Aug;22(4):378-81. doi: 10.1016/s1098-7339(97)80015-6.

Abstract

Background and objectives: Changes in uterine tone have been postulated as the cause of fetal bradycardia following subarachnoid administration of fentanyl for labor analgesia. Such a case occurred in a 20-year-old parturient with an intrauterine pressure catheter in place.

Methods: The patient was given intravenous terbutaline, after which contractions ceased for 20-30 minutes and then resumed.

Results: The patient underwent successful cesarean delivery. Retrospective analysis of the data revealed a significant increase in uterine tone and contractions following fentanyl administration.

Conclusions: This case supports the view that changes in uterine tone, producing a hyperdynamic contractile state and a resulting decrease in uteroplacental perfusion, may explain the fetal bradycardia following subarachnoid opioid administration. Cases that do not resolve spontaneously may respond to intravenous terbutaline.

MeSH terms

  • Adult
  • Analgesia, Obstetrical / adverse effects*
  • Analgesics, Opioid / adverse effects*
  • Bradycardia / chemically induced*
  • Female
  • Fentanyl / adverse effects*
  • Heart Rate, Fetal / drug effects*
  • Humans
  • Pregnancy
  • Subarachnoid Space
  • Uterus / drug effects*

Substances

  • Analgesics, Opioid
  • Fentanyl