Abstract
Optimal management of fungemia in neutropenic patients is still controversial. Several reports have already stressed the poor prognosis in invasive candidiasis (80% mortality in several reports). Therefore granulocyte transfusions would appear to be useful in the management of these infections. We report the use of rhG-CSF-primed granulocyte transfusions plus amphotericin B in two neutropenic patients who developed life-threatening systemic fungal infections. This approach was successful and both patients fully recovered from the infection.
MeSH terms
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Acute Disease
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Adult
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Amphotericin B / therapeutic use
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Antifungal Agents / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Candidiasis / drug therapy
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Candidiasis / etiology
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Candidiasis / therapy*
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Combined Modality Therapy
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Cytarabine / administration & dosage
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Cytarabine / adverse effects
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Fungemia / drug therapy
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Fungemia / etiology
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Fungemia / therapy*
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Granulocyte Colony-Stimulating Factor / administration & dosage
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Granulocyte Colony-Stimulating Factor / pharmacology*
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Hematopoiesis / drug effects*
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Humans
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Leukemia, Myeloid / complications
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Leukemia, Myeloid / drug therapy
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Leukocyte Transfusion*
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Mitoxantrone / administration & dosage
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Mitoxantrone / adverse effects
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Neutropenia / chemically induced
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Neutropenia / complications*
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / pharmacology
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Remission Induction
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Treatment Outcome
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Waldenstrom Macroglobulinemia / drug therapy
Substances
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Antifungal Agents
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Recombinant Proteins
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Cytarabine
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Granulocyte Colony-Stimulating Factor
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Amphotericin B
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Mitoxantrone