Abstract
A molecule isolated from the peritoneal fluids of women undergoing laparoscopy for in-vitro fertilization techniques has been chemically characterized and identified as 1-palmitic-3-phosphorylcholine (lysophosphatidylcholine, LPC). This lipid is able, at physiological concentrations, to completely inhibit sperm motility in vitro in a dose-dependent way. Synthetic LPC induced rapid and complete arrest of sperm motility when added to sperm suspensions at physiological concentrations without any damage to cell membranes. Taken together, these results suggest that LPC may represent a previously unrecognized in-vivo modulator of human sperm motility.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ascitic Fluid / chemistry*
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Female
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Humans
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In Vitro Techniques
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Infertility, Female / etiology
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Infertility, Female / physiopathology
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Lysophosphatidylcholines / isolation & purification*
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Lysophosphatidylcholines / pharmacology*
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Male
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Phosphatidylserines / isolation & purification
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Phosphatidylserines / pharmacology
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Phosphatidylserines / physiology
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Protein Kinase C / physiology
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Sperm Immobilizing Agents / isolation & purification*
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Sperm Immobilizing Agents / pharmacology*
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Sperm Motility / drug effects*
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Sperm Motility / physiology*
Substances
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Lysophosphatidylcholines
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Phosphatidylserines
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Sperm Immobilizing Agents
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Protein Kinase C