Synthesis, antimicrobial and genotoxic properties of some benzoimidazole derivatives

Farmaco. 1997 Apr;52(4):231-5.

Abstract

A number of 1H-benzoimidazol-2-ylamine and of 1-methyl-1H-benzoimidazol-2-ylamine derivatives were synthesized and the crystal and molecular structure of N-[4-(2-amino-benzoimidazole-1-sulfonyl)-phenyl] acetamide was determined by X-ray diffraction analysis. The compounds obtained were investigated for antimicrobial and genotoxic activities.

MeSH terms

  • Anti-Infective Agents / chemical synthesis
  • Anti-Infective Agents / pharmacology*
  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / pharmacology
  • Imidazoles / chemical synthesis
  • Imidazoles / pharmacology*
  • Imidazoles / toxicity
  • Molecular Structure
  • Mutagenicity Tests
  • Mutagens / chemical synthesis
  • Mutagens / toxicity

Substances

  • Anti-Infective Agents
  • Antifungal Agents
  • Imidazoles
  • Mutagens