This study analyzed the efficacy of an interposed vein conduit graft in eliminating symptoms of painful neuroma of sensory nerves of the hand and preventing recurrence after excising the pathologic tissue and bridging the concomitant gap with the distal nerve segment. Twenty-three patients underwent reconstruction of 25 palmar sensory nerve gaps ranging from 12 mm to 28 mm, as well as 2 dorsal gaps of 32 mm and 35 mm, respectively. Eighteen patients had symptomatic painful neuromas. Subjective and objective evaluation criteria were employed for assessment and were compared with data obtained from primary direct suturing in 25 digital nerves of 21 patients. Electrophysiologic measurements, including sensory nerve action potential and conduction velocity, were similar, with both groups having values significantly lower than normal control values. Two-point discrimination measurements were slightly inferior for the vein conduit-reconstructed nerves compared with results attained after direct suturing. However, neuroma symptoms were eliminated, and in combination with the return of adequate sensibility, all but 1 patient resumed full hand function.