Skeletal metastases from soft-tissue sarcomas. Incidence, patterns, and radiological features

J Bone Joint Surg Br. 1997 Jul;79(4):548-52. doi: 10.1302/0301-620x.79b4.7372.

Abstract

We reviewed 277 patients with soft-tissue sarcoma (STS) treated between 1975 and 1995 to study the incidence, distribution, time of appearance, and radiological findings of skeletal metastases. Of these, 28 (10.1%) had metastases within a mean period of 18.6 months after admission. The incidence of skeletal metastases differed among the histological subtypes of sarcoma; alveolar soft-part sarcoma, dedifferentiated liposarcoma, angiosarcoma, and rhabdomyosarcoma tended to show higher incidences. The regional bones close to the primary tumour were affected in 13 (46.4%) of the 28 patients, and the axial bones in 18 (64.3%). Radiologically, the metastatic bony lesions predominantly showed osteolytic changes, and there were pathological fractures in 21 of 44 lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bone Neoplasms / complications
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / secondary*
  • Child
  • Female
  • Fractures, Spontaneous / complications
  • Histiocytoma, Benign Fibrous / complications
  • Histiocytoma, Benign Fibrous / secondary
  • Humans
  • Male
  • Middle Aged
  • Radiography
  • Rhabdomyosarcoma / complications
  • Rhabdomyosarcoma / secondary
  • Sarcoma / complications
  • Sarcoma / diagnostic imaging
  • Sarcoma / secondary*
  • Soft Tissue Neoplasms / complications
  • Soft Tissue Neoplasms / pathology*