Abstract
The effect of indole alkaloids from Sickingia williamsii Standl. (Rubiaceae) on the effects of morphine withdrawal have been examined in-vitro. All the indole alkaloids isolated from S. williamsii (10(-4), 5 x 10(-5) and 10(-5) M) significantly and in a concentration-dependent manner reduced the effects of morphine withdrawal on the guinea-pig ileum. The results suggest that these alkaloids might be potential anti-addictive agents.
MeSH terms
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Acetylcholine / administration & dosage
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Acetylcholine / pharmacology
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Alkaloids / pharmacology
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Alkaloids / therapeutic use*
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Animals
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Electric Stimulation
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Guinea Pigs
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Ileum / drug effects*
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Ileum / pathology
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Indoles / metabolism
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Indoles / pharmacology
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Indoles / therapeutic use*
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Male
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Morphine / adverse effects*
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Morphine Dependence / drug therapy
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Naloxone / administration & dosage
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Naloxone / pharmacology
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Naloxone / therapeutic use
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Narcotic Antagonists / administration & dosage
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Narcotic Antagonists / pharmacology
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Narcotic Antagonists / therapeutic use
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Narcotics / adverse effects*
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Rubiaceae*
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Substance Withdrawal Syndrome / drug therapy*
Substances
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Alkaloids
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Indoles
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Narcotic Antagonists
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Narcotics
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Naloxone
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Morphine
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Acetylcholine