Transient liver accumulation of Tc-99m phytate in hepatocellular carcinoma after percutaneous ethanol injection

Clin Nucl Med. 1997 Aug;22(8):550-2. doi: 10.1097/00003072-199708000-00008.

Abstract

Purpose: We report that colloid liver scanning gave early evidence of the return to normal of Kupffer cell functions after ethanol injections into the liver.

Patient and methods: A 71-year-old man with hepatocellular carcinoma received percutaneous ethanol injections twice of 15 mL of ethanol, 1 week apart.

Results: Abdominal CT after the second injection showed an irregularly shaped low-density area in the left side of the tumor, extending outside the tumor. Liver imaging with To-99m phytate 10 days later showed increased activity at the corresponding site. Thirty days after the second injection, liver imaging did not show high activity.

Conclusions: Ethanol that leaked into the normal part of the liver probably temporarily activated Kupffer cell function.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / administration & dosage*
  • Carcinoma, Hepatocellular / complications
  • Carcinoma, Hepatocellular / diagnostic imaging*
  • Carcinoma, Hepatocellular / drug therapy
  • Ethanol / administration & dosage*
  • Humans
  • Kupffer Cells / diagnostic imaging
  • Kupffer Cells / drug effects
  • Liver Cirrhosis / complications
  • Liver Neoplasms / complications
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / drug therapy
  • Male
  • Organotechnetium Compounds*
  • Phytic Acid*
  • Radionuclide Imaging
  • Radiopharmaceuticals*

Substances

  • Antineoplastic Agents
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium phytate
  • Ethanol
  • Phytic Acid