Abstract
This study shows that the broad anti-HLA antibody response against cryopreserved valved allografts used for surgical repair of congenital heart disease persists beyond 1 year after implantation. In 3 patients, there were clearly defined HLA antibody specificities consistent with the HLA phenotypes of the patients, i.e., the panel-reactive antibody was directed against major alloantigen groups that were not expressed by the antibody responders.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Aortic Valve / transplantation*
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Child
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Child, Preschool
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Cryopreservation
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Epitopes*
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Heart Defects, Congenital / surgery*
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Histocompatibility Antigens Class I / immunology*
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Humans
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Infant
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Infant, Newborn
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Isoantibodies / blood*
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Prospective Studies
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Pulmonary Valve / transplantation*
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Time Factors
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Transplantation, Homologous
Substances
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Epitopes
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Histocompatibility Antigens Class I
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Isoantibodies