In this study, we review research conducted in the La Spezia district during 1989, 1992, and 1994, using lichens and moss as indicators of air pollution. SO2 pollution was examined by means of an Index of Atmospheric Purity (IAP) based on the frequency of epiphytic lichen within a sampling grid. Metal deposits were estimated using the lichen Parmelia caperata and the moss Hypnum cupressiforme as bioaccumulators. IAP maps show progressive air quality improvement from 1989 to 1994. This trend correlates to a decrease in SO2 emissions during recent years that is attributed to the use of methane for residential heating and the closing of a coal-fired power plant. Metal contamination maps show that the most polluted area is now in the southeastern part of the gulf. The pattern of pollution coincides with the location of the chief pollution sources in the area. From 1989 to 1994, the metal concentrations in lichens decreased, but metal deposits in the southeastern area were cause for concern. High concentrations of lead in the area are related to emissions from a waste incinerator and a plant that produces lead oxide. Epidemiological investigations reveal that the area population has the highest levels of lead in their blood. The use of bioindicators and bioaccumulators permits long-term and large-scale monitoring of environmental pollutant levels in full agreement with traditional methods.