[Study of in vitro activity of 3 cephalosporins and their combination with 2 beta-lactamase inhibitors against 4 enterobacteria strains producing extended spectrum beta-lactamase]

C Cattoen; D Duflos; L Bouillet; C Chatelain; E Mazars

[Study of in vitro activity of 3 cephalosporins and their combination with 2 beta-lactamase inhibitors against 4 enterobacteria strains producing extended spectrum beta-lactamase]

Pathol Biol (Paris). 1997 May;45(5):425-9.

[Article in French]

Authors

C Cattoen¹, D Duflos, L Bouillet, C Chatelain, E Mazars

Affiliation

¹ Département de Microbiologie, Centre Hospitalier, Valenciennes, France.

PMID: 9296097

Abstract

The in vitro antibacterial activity of cefotaxime, cefepime and cefpirome was evaluated alone and in association with two beta-lactamase inhibitors: clavulanic acid and sulbactam against 65 extended broad spectrum beta-lactamase producing enterobacteriaceae strains [Klebsiella pneumoniae (35), Proteus mirabilis (9), Escherichia coli (11), Enterobacter aerogenes (10)]. The lowest MICs were observed for cefepime and cefpirome used alone. In association with inhibitors cefotaxime was less effective against E. aerogenes. Most isolates of K. pneumoniae, P. mirabilis, E. coli were susceptible to all the different tested associations.

MeSH terms

Cephalosporins / administration & dosage
Cephalosporins / pharmacology*
Drug Therapy, Combination / pharmacology*
Enterobacter / classification
Enterobacter / drug effects*
Enterobacter / enzymology
Enzyme Inhibitors / administration & dosage
Enzyme Inhibitors / pharmacology*
Escherichia coli / drug effects
Escherichia coli / enzymology
In Vitro Techniques
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / enzymology
Microbial Sensitivity Tests
Proteus mirabilis / drug effects
Proteus mirabilis / enzymology
beta-Lactamase Inhibitors*
beta-Lactamases / metabolism

Substances

Cephalosporins
Enzyme Inhibitors
beta-Lactamase Inhibitors
beta-Lactamases