[Effects of PDGF AB on extracellular matrix synthesis by human mammary fibroblasts]

C Palumbo; F Vasaturo; G Zelli; P Cardelli; G Rubinacci; M Modesti; S Scarpa

[Effects of PDGF AB on extracellular matrix synthesis by human mammary fibroblasts]

G Chir. 1997 Jun-Jul;18(6-7):337-9.

[Article in Italian]

Authors

C Palumbo¹, F Vasaturo, G Zelli, P Cardelli, G Rubinacci, M Modesti, S Scarpa

Affiliation

¹ Dipartimento di Medicina Sperimentale e Patologia, Università degli Studi La Sapienza, Roma.

PMID: 9296593

Abstract

PDGF AB effect on extracellular matrix protein synthesis and release by a primary culture of non transformed human mammary fibroblasts was analyzed. Primarily PDGF AB induced a modified protein distribution, with a global enhancement of secreted proteins as compared to intracytoplasmatic proteins. Furthermore, an increase in synthesis and release of the extracellular matrix proteins such as fibronectin and type I and IV collagens upon PDGF AB treatment with specific immunoprecipitation was demonstrated.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Autoradiography
Breast Neoplasms / metabolism
Breast Neoplasms / pathology*
Extracellular Matrix Proteins / biosynthesis*
Extracellular Matrix Proteins / drug effects
Female
Fetal Hemoglobin / metabolism*
Fibroadenoma / metabolism
Fibroadenoma / pathology*
Humans
In Vitro Techniques
Platelet-Derived Growth Factor / pharmacology*
Precipitin Tests

Substances

Extracellular Matrix Proteins
Platelet-Derived Growth Factor
Fetal Hemoglobin