Research examining the MMPI's ability to predict premature termination has yielded discrepant findings. This may be due, in part, to previous operational definitions of premature termination and extensive analysis on inadequately sized samples. This study addressed both methodological issues. This study examined MMPI-2 clinical Scales 2, 4, and 7 and content scales DEP, ASP, ANX, and TRT as predictors of premature termination and psychotherapeutic outcome in 86 adult clients seeking services at a university-based clinic. Premature termination was operationalized as therapists' ratings of clients' readiness for termination. Psychotherapeutic outcome was operationalized as therapists' ratings of the clients' progress in therapy goals, improvement in global psychopathology, improvement in current functioning, and global improvement. None of MMPI-2 scales predicted readiness for termination. However, significant associations were found between specific MMPI-2 scales and three of the four outcome ratings, with the content scales emerging as better predictors. The implications of these findings are discussed to help guide future research in this area.