Abstract
Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects. Slight degrees of primarily renal toxicity occurred with 2 mg/kg/day; 20 mg/kg/day caused multiple toxic effects, including renal tubular neoplasms.
MeSH terms
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Adenocarcinoma / chemically induced
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Adenoma / chemically induced
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Animals
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Body Weight / drug effects
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Butadienes / administration & dosage
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Butadienes / toxicity*
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Coproporphyrins / urine
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Diet
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Female
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Kidney / drug effects
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Kidney / pathology
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Kidney Neoplasms / chemically induced*
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Kidney Tubules*
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Male
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Neoplasms / etiology
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Organ Size / drug effects
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Rats
Substances
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Butadienes
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Coproporphyrins