Therapeutic efficacy of clindamycin in combination with quinine for treating uncomplicated malaria in a village dispensary in Gabon

M Vaillant; P Millet; A Luty; P Tshopamba; F Lekoulou; J Mayombo; A J Georges; P Deloron

doi:10.1046/j.1365-3156.1997.d01-411.x

Therapeutic efficacy of clindamycin in combination with quinine for treating uncomplicated malaria in a village dispensary in Gabon

Trop Med Int Health. 1997 Sep;2(9):917-9. doi: 10.1046/j.1365-3156.1997.d01-411.x.

Authors

M Vaillant¹, P Millet, A Luty, P Tshopamba, F Lekoulou, J Mayombo, A J Georges, P Deloron

Affiliation

¹ Centre International de Recherches Médicales de Franceville, Gabon.

PMID: 9315051
DOI: 10.1046/j.1365-3156.1997.d01-411.x

Abstract

The efficacy of a 3-day clindamycin-quinine regimen to treat clinical malaria attacks was investigated in 256 children from western Gabon. Treatment was well tolerated by all of the children and its efficacy was higher than 97% by day 20. Thus this 3-day clindamycin-quinine regimen might constitute a potential alternative to chloroquine for treating clinical malarial attacks in children from Gabon.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / adverse effects
Anti-Bacterial Agents / therapeutic use*
Antimalarials / administration & dosage
Antimalarials / adverse effects
Antimalarials / therapeutic use*
Child
Clindamycin / administration & dosage
Clindamycin / adverse effects
Clindamycin / therapeutic use*
Drug Therapy, Combination
Female
Gabon
Humans
Malaria, Falciparum / drug therapy*
Male
Quinine / administration & dosage
Quinine / adverse effects
Quinine / therapeutic use*

Substances

Anti-Bacterial Agents
Antimalarials
Clindamycin
Quinine