Endolymphatic sac tumor: a case report and review of the literature

Surg Neurol. 1997 Oct;48(4):368-73. doi: 10.1016/s0090-3019(96)00553-8.

Abstract

Background: Papillary tumors of the temporal bone are very rare but aggressive neoplasms. In the past, a middle-ear origin was presumed. Only recently convincing evidence exists that these tumors in fact arise from the endolymphatic sac.

Methods: We present a case of an endolymphatic sac tumor (ELST) with detailed clinical, imaging, operative, and pathologic data. The literature on this rare tumor type is reviewed.

Results: This 63-year-old woman had a progressive mass lesion in the temporal bone for a period of more than 35 years, resulting in unilateral fifth to eleventh cranial nerve palsy, progressive ataxia, and a pyramidal and pseudobulbar syndrome. Computerized tomography (CT) and magnetic resonance imaging (MRI) showed a tumor invading the pars squamosa and petrosa of the temporal bone, and extending into the middle and posterior fossa. Angiography demonstrated a hypervascular tumor mass. The patient underwent surgery, with nonradical removal of a tumor. Histologic examination demonstrated a papillary ELST. A search through the literature revealed 36 patients with ELST, based on convincing anatomic and histologic considerations.

Conclusions: It is important to make a distinction between ELST and the more benign middle-ear adenomas, since this leads to a different treatment and prognosis. ELST frequently invades the surrounding structures and extends intracranially. The treatment of choice is a radical resection, although complete resection is impossible in most of the cases. The value of adjunctive radiation therapy remains controversial.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenoma / diagnostic imaging
  • Adenoma / pathology*
  • Adenoma / surgery
  • Carotid Artery, Internal
  • Cerebral Angiography
  • Craniopharyngioma / pathology
  • Craniopharyngioma / surgery
  • Ear Neoplasms / diagnostic imaging
  • Ear Neoplasms / pathology
  • Ear Neoplasms / surgery*
  • Endolymphatic Sac / diagnostic imaging
  • Endolymphatic Sac / pathology
  • Endolymphatic Sac / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neoplasm Invasiveness
  • Skull Neoplasms / pathology
  • Skull Neoplasms / surgery
  • Temporal Bone / pathology
  • Tomography, X-Ray Computed