Cisplatin and acute tubular necrosis

Clin Oncol (R Coll Radiol). 1997;9(4):267-8. doi: 10.1016/s0936-6555(97)80016-7.

Abstract

We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma. This was associated with polyuria but no significant hyponatraemia. Full recovery occurred because of early pick up, emphasizing the need for careful fluid balance monitoring of patients receiving cisplatin chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / adverse effects*
  • Cisplatin / adverse effects*
  • Humans
  • Kidney Tubular Necrosis, Acute / chemically induced*
  • Kidney Tubular Necrosis, Acute / diagnosis
  • Male
  • Teratoma / drug therapy
  • Testicular Neoplasms / drug therapy

Substances

  • Antineoplastic Agents
  • Cisplatin