Development and evaluation of a kit formulation for the preparation of 99mTc-DMP-HSA, a new tracer agent for radionuclide ventriculography

K A Verbeke; C W Schiepers; D N Wyndaele; J A Baetens; G N Verbeke; M J De Roo; A M Verbruggen

doi:10.1016/s0969-8051(97)00019-x

Development and evaluation of a kit formulation for the preparation of 99mTc-DMP-HSA, a new tracer agent for radionuclide ventriculography

Nucl Med Biol. 1997 Aug;24(6):571-8. doi: 10.1016/s0969-8051(97)00019-x.

Authors

K A Verbeke¹, C W Schiepers, D N Wyndaele, J A Baetens, G N Verbeke, M J De Roo, A M Verbruggen

Affiliation

¹ Laboratory of Radiopharmaceutical Chemistry, K.U. Leuven, Belgium.

PMID: 9316087
DOI: 10.1016/s0969-8051(97)00019-x

Abstract

This study presents the development of a kit formulation for the preparation of 99mTc-DMP-HSA, followed by a comparison of such kit-prepared 99mTc-DMP-HSA to 99mTc-RBCs in a volunteer. Reconstitution of the labeling kits with up to 5.55 GBq 99mTc afforded 99mTc-DMP-HSA preparations with a > 95% radiochemical purity for up to 8 h. Only minor differences were observed in the global distribution of both tracer agents, whereas the calculated ejection fractions were almost identical. The effective dose equivalent of 99mTc-DMP-HSA is 8.68 microSv/MBq.

MeSH terms

Humans
Male
Organotechnetium Compounds* / chemistry
Organotechnetium Compounds* / pharmacokinetics
Quality Control
Radiation Dosage
Radionuclide Ventriculography*
Reagent Kits, Diagnostic
Sulfhydryl Compounds* / chemistry
Sulfhydryl Compounds* / pharmacokinetics
Technetium Tc 99m Aggregated Albumin* / chemistry
Technetium Tc 99m Aggregated Albumin* / pharmacokinetics

Substances

Organotechnetium Compounds
Reagent Kits, Diagnostic
Sulfhydryl Compounds
Technetium Tc 99m Aggregated Albumin
technetium Tc 99m 2,3-dimercaptopropionic acid