From indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

MeSH terms

• Animals
• Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
• Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
• Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
• Anti-Inflammatory Agents, Non-Steroidal / toxicity
• Carrageenan / toxicity
• Chromium Radioisotopes
• Cyclooxygenase 1
• Cyclooxygenase 2
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors / chemical synthesis
• Cyclooxygenase Inhibitors / pharmacology*
• Cyclooxygenase Inhibitors / therapeutic use
• Cyclooxygenase Inhibitors / toxicity
• Digestive System / drug effects
• Edema / chemically induced
• Edema / prevention & control
• Feces / chemistry
• Fever / chemically induced
• Fever / drug therapy
• Indomethacin / analogs & derivatives*
• Indomethacin / chemical synthesis
• Indomethacin / pharmacology
• Indomethacin / therapeutic use
• Indomethacin / toxicity
• Isoenzymes / drug effects*
• Membrane Proteins
• Molecular Conformation
• Molecular Structure
• Neoplasm Proteins / antagonists & inhibitors
• Prostaglandin-Endoperoxide Synthases / drug effects*
• Rats
• Structure-Activity Relationship
• Substrate Specificity
• Tumor Cells, Cultured