An analysis of results of 315 combined operations for gastric cancer with the T3 and T4 degrees of invasion has shown that the rational multicomponent surgical, anesthesiological and therapeutic maintenance of surgical interventions for gastric cancer is the main factor responsible for the outcome of the treatment. The proposed scheme of the multicomponent rational maintenance of the combined surgical interventions allowed to reduce frequency of cardiopulmonary complications to 18.2%, pyoseptic complications to 7% and postoperative lethality to 13.2%.