In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes

Adv Pharmacol. 1998:42:493-6. doi: 10.1016/s1054-3589(08)60796-6.

Authors

L B MacMillan¹, P P Lakhlani, L Hein, M Piascik, T Z Guo, D Lovinger, M Maze, L E Limbird

Affiliation

¹ Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.

PMID: 9327947
DOI: 10.1016/s1054-3589(08)60796-6

No abstract available

MeSH terms

Adrenergic alpha-Agonists / pharmacology
Amino Acid Sequence
Amino Acid Substitution
Animals
Asparagine
Aspartic Acid
Blood Pressure / drug effects
Brain / metabolism*
Cell Line
Conserved Sequence
Down-Regulation
Locus Coeruleus / physiology
Mice
Mice, Mutant Strains
Mutagenesis, Site-Directed
Point Mutation
Receptors, Adrenergic, alpha-2 / biosynthesis
Receptors, Adrenergic, alpha-2 / genetics
Receptors, Adrenergic, alpha-2 / physiology*
Recombinant Proteins / metabolism
Recombination, Genetic*
Transcription, Genetic

Substances

Adra2a protein, mouse
Adrenergic alpha-Agonists
Receptors, Adrenergic, alpha-2
Recombinant Proteins
Aspartic Acid
Asparagine