Synthesis of Tn and sialyl Tn antigen-lipid A analog conjugates for synthetic vaccines

K Miyajima; T Nekado; K Ikeda; K Achiwa

doi:10.1248/cpb.45.1544

Synthesis of Tn and sialyl Tn antigen-lipid A analog conjugates for synthetic vaccines

Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1544-6. doi: 10.1248/cpb.45.1544.

Authors

K Miyajima¹, T Nekado, K Ikeda, K Achiwa

Affiliation

¹ School of Pharmaceutical Sciences, University of Shizuoka, Japan.

PMID: 9332007
DOI: 10.1248/cpb.45.1544

Abstract

Conjugates of Tn and sialyl Tn antigen with N-teradecanoyl L-seryl-beta-alanine-containing D-glucosamine derivatives structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers or HIV.

MeSH terms

Antigens, Tumor-Associated, Carbohydrate / chemistry*
Carbohydrate Conformation
Carbohydrate Sequence
Lipid A / chemistry*
Molecular Sequence Data
Vaccines, Synthetic / chemistry*

Substances

Antigens, Tumor-Associated, Carbohydrate
Lipid A
Vaccines, Synthetic
sialosyl-Tn antigen