Structure of a conserved RNA component of the peptidyl transferase centre

Nat Struct Biol. 1997 Oct;4(10):775-8. doi: 10.1038/nsb1097-775.

Abstract

The structure of a conserved hairpin loop involved in peptidyl-tRNA recognition by 50S ribosomal subunits has been solved by NMR. The loop is closed by a novel G-C base pair and presents guanine residues for RNA recognition.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Composition
  • Base Sequence
  • Conserved Sequence
  • Models, Molecular
  • Nuclear Magnetic Resonance, Biomolecular
  • Nucleic Acid Conformation*
  • Oligoribonucleotides / chemistry*
  • Peptidyl Transferases / chemistry*
  • Peptidyl Transferases / metabolism*
  • RNA, Ribosomal, 23S / chemistry*
  • RNA, Ribosomal, 23S / metabolism*
  • Ribosomes / metabolism*
  • Ribosomes / ultrastructure
  • Thermodynamics

Substances

  • Oligoribonucleotides
  • RNA, Ribosomal, 23S
  • Peptidyl Transferases