CSF antigliadin antibodies and the Ramsay Hunt syndrome

Neurology. 1997 Oct;49(4):1131-3. doi: 10.1212/wnl.49.4.1131.

Abstract

Although the association between celiac disease and progressive myoclonic ataxia is well recognized, in each of the reported cases the neurologic features began in middle adult life and usually in patients who had clinical or laboratory evidence of malabsorption. We report a case of progressive myoclonic ataxia and epilepsy (Ramsay Hunt syndrome) that began in childhood. In this patient there were no features suggestive of gluten intolerance. The presence of antigliadin antibodies in the serum and CSF suggested celiac disease was the cause of the patient's neurologic syndrome. Duodenal morphologic abnormalities reversed with treatment but no major changes were noted in the patient. Celiac disease should be considered in the differential diagnosis of myoclonic ataxia at any age, even in the absence of clinical evidence of gluten-sensitive enteropathy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies / cerebrospinal fluid*
  • Celiac Disease / complications
  • Celiac Disease / pathology
  • Duodenum / pathology
  • Female
  • Gliadin / immunology*
  • Humans
  • Myoclonic Cerebellar Dyssynergia / cerebrospinal fluid*
  • Myoclonic Cerebellar Dyssynergia / complications

Substances

  • Antibodies
  • Gliadin