Phase II clinical trial of carboplatin in canine transitional cell carcinoma of the urinary bladder

R Chun; D W Knapp; W R Widmer; D B DeNicola; N W Glickman; T Kuczek; A Degortari; C M Han

doi:10.1111/j.1939-1676.1997.tb00465.x

Phase II clinical trial of carboplatin in canine transitional cell carcinoma of the urinary bladder

J Vet Intern Med. 1997 Sep-Oct;11(5):279-83. doi: 10.1111/j.1939-1676.1997.tb00465.x.

Authors

R Chun¹, D W Knapp, W R Widmer, D B DeNicola, N W Glickman, T Kuczek, A Degortari, C M Han

Affiliation

¹ Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.

PMID: 9348494
DOI: 10.1111/j.1939-1676.1997.tb00465.x

Abstract

Fourteen dogs with histologically-confirmed transitional cell carcinoma (TCC) of the urinary bladder were treated with 300 mg/m2 carboplatin every 3 weeks. Response to therapy was assessed with abdominal radiography, double contrast cystography, urinary bladder ultrasonography and thoracic radiography before therapy and at 6-week intervals during therapy. Dogs were monitored for hematologic toxicity with a CBC and platelet count performed immediately before and 10 to 14 days after carboplatin treatment. Tumor responses included progressive disease in 11 dogs and stable disease in 1 dog. Two dogs were euthanized due to carboplatin toxicity before assessment of tumor response. Toxicity included thrombocytopenia with or without neutropenia in 7 dogs and gastrointestinal toxicity in 6 dogs. Carboplatin therapy was not beneficial in the treatment of TCC in the 14 dogs in this study.

Publication types

Clinical Trial
Clinical Trial, Phase II
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / adverse effects
Antineoplastic Agents / pharmacokinetics
Antineoplastic Agents / therapeutic use*
Carboplatin / adverse effects
Carboplatin / pharmacokinetics
Carboplatin / therapeutic use*
Carcinoma, Transitional Cell / drug therapy
Carcinoma, Transitional Cell / pathology
Carcinoma, Transitional Cell / veterinary*
Dog Diseases / diagnostic imaging
Dog Diseases / drug therapy*
Dog Diseases / pathology
Dogs
Dose-Response Relationship, Drug
Female
Incidence
Male
Neutropenia / chemically induced
Neutropenia / epidemiology
Neutropenia / veterinary
Radiography, Abdominal / methods
Radiography, Abdominal / veterinary
Radiography, Thoracic / veterinary
Thrombocytopenia / chemically induced
Thrombocytopenia / epidemiology
Thrombocytopenia / veterinary
Ultrasonography
Urinary Bladder / diagnostic imaging
Urinary Bladder / drug effects
Urinary Bladder / pathology
Urinary Bladder Neoplasms / drug therapy
Urinary Bladder Neoplasms / pathology
Urinary Bladder Neoplasms / veterinary*

Substances

Antineoplastic Agents
Carboplatin