Five year treatment with IGF-I of a patient with Laron syndrome in Slovenia (a follow-up report)

J Pediatr Endocrinol Metab. 1997 Jul-Aug;10(4):443-7. doi: 10.1515/jpem.1997.10.4.443.

Abstract

This is a follow-up report of a 14 1/2 year-old boy with Laron syndrome, who received twice daily therapy with IGF-I 120 micrograms/kg for 5 years that resulted in a linear growth of 40 cm. Concomitantly he became very obese which is attributed to IGF-I action via the insulin receptors.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthropometry
  • Body Height
  • Child
  • Follow-Up Studies
  • Growth Disorders / drug therapy*
  • Humans
  • Insulin-Like Growth Factor I / administration & dosage
  • Insulin-Like Growth Factor I / therapeutic use*
  • Male
  • Mutation*
  • Puberty, Delayed
  • Receptors, Somatotropin / genetics*
  • Recombinant Proteins / therapeutic use
  • Slovenia
  • Syndrome

Substances

  • Receptors, Somatotropin
  • Recombinant Proteins
  • Insulin-Like Growth Factor I