Poly(ADP-ribose) polymerase (PARP) revisited. A new role for an old enzyme: PARP involvement in neurodegeneration and PARP inhibitors as possible neuroprotective agents

Ann N Y Acad Sci. 1997 Oct 15:825:366-79. doi: 10.1111/j.1749-6632.1997.tb48447.x.
No abstract available

MeSH terms

  • Animals
  • Benzamides / pharmacology
  • Benzoates / pharmacology
  • Benzoic Acid
  • Brain / drug effects
  • Brain / metabolism*
  • Catecholamines / metabolism*
  • Cell Survival / drug effects
  • Cells, Cultured
  • Cerebellum / cytology*
  • Cerebellum / physiology
  • Dopamine / metabolism
  • Enzyme Inhibitors / pharmacology*
  • Glutamic Acid / toxicity*
  • MPTP Poisoning
  • Mice
  • Mice, Inbred C57BL
  • Neurons / cytology
  • Neurons / drug effects*
  • Neurons / physiology
  • Neuroprotective Agents / pharmacology*
  • Neurotoxins / toxicity
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Poly(ADP-ribose) Polymerases / biosynthesis
  • Poly(ADP-ribose) Polymerases / metabolism*
  • RNA, Messenger / biosynthesis
  • Rats
  • Transcription, Genetic / drug effects

Substances

  • Benzamides
  • Benzoates
  • Catecholamines
  • Enzyme Inhibitors
  • Neuroprotective Agents
  • Neurotoxins
  • Poly(ADP-ribose) Polymerase Inhibitors
  • RNA, Messenger
  • Glutamic Acid
  • benzamide
  • Benzoic Acid
  • Poly(ADP-ribose) Polymerases
  • Dopamine