Global dimensional complexity of multichannel EEG in mild Alzheimer's disease and age-matched cohorts

Dement Geriatr Cogn Disord. 1997 Nov-Dec;8(6):343-7. doi: 10.1159/000106653.

Abstract

Multichannel EEG as sequence of momentary brain field maps constitutes a trajectory through K-dimensional state space (K = number of channels); the complexity of this trajectory is assessed by the nonlinear measure of global correlation dimension (Global Dimensional Complexity, GDC) with the number of electrodes as embedding dimension. We analyzed eyes-closed EEG of three age-matched subject groups: mild Alzheimer's disease (AD; n = 21), mild cognitive impairment (29) and subjective memory complaint (29). Kruskal-Wallis statistics showed an overall effect between groups. AD patients differed significantly (GDC = 4.56) from mild cognitive impairments (GDC = 4.98) and from subjective memory complaints (GDC = 4.93). GDC also had significant positive correlations with mental condition and performance (MMSE and WAIS-R scores). Thus, the dynamics of brain state development over time in mild AD differs from that in mild cognitive impairment and in subjective memory complaint cases.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Alzheimer Disease / complications
  • Alzheimer Disease / diagnosis*
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology
  • Cohort Studies
  • Electroencephalography*
  • Female
  • Humans
  • Male
  • Memory Disorders / diagnosis
  • Memory Disorders / etiology
  • Middle Aged
  • Neuropsychological Tests
  • Prospective Studies
  • Severity of Illness Index
  • Statistics, Nonparametric