The levels of the immunoglobulins (IgG, IgA, IgM), complements (C3, C4) and circulating immune complex (CIC) of the patients were measured before and after implantation of the machinable bioactive glass ceramics in maxillofacial surgery. No significant changes were detected. The results indicate that the patients' immunologic function and status were not affected by the material and machinable bioactive glass ceramics is good bloodcompatibility.