[A study on the effect of emodin on smooth muscle cell proliferation]

Zhonghua Nei Ke Za Zhi. 1996 Mar;35(3):157-9.
[Article in Chinese]

Abstract

By using smooth muscle cell (SMC) culture in vitro and H3-TdR incorporation technique, we tested the effect of Emodin on SMC proliferation in three groups: (1) Normal rabbit iliac artery, (2) atherosclerotic rabbit iliac artery, (3) atherosclerotic rabbit iliac artery after PTA. These data indicated: Emodin has antiproliferative effect on SMC, which is dose dependent; it blocks the transition of SMC cycle from G0 to S. In PTA group it exerts a more significant proliferative effect than in the normal one. This is a the first report of Emodin's effect on SMC proliferation, it implies that the drug may be used clinically to prevent restenosis after PTCA.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angioplasty, Balloon / adverse effects
  • Animals
  • Arteriosclerosis / pathology*
  • Arteriosclerosis / therapy
  • Cell Division / drug effects
  • DNA / biosynthesis
  • Emodin / pharmacology*
  • Iliac Artery
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / drug effects*
  • Rabbits

Substances

  • DNA
  • Emodin