Abstract
Twenty-six cancer patients (pts) with chemotherapy-related neutropenic fever were treated with vancomycin 30 mg/m2/day i.v. every 12 hrs, imipenem 1500 mg/day i.v. every 8 hrs, and pefloxacin 800 mg/day i.v. every 12 hrs. Twelve fevers of unknown origin (FUO), 10 gram-positive, 3 gram-negative and 1 mycoplasma were also treated. Globally, cure was observed in 22 pts (84%) and failure in 4 pts (16%); in gram-positive infections alone, cure was observed in 10 pts (80%) and failure in 4 pts (20%). Defervescence was obtained within 3 days in 77% pts. No relevant side effects were observed.
MeSH terms
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Anti-Bacterial Agents / therapeutic use*
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Anti-Infective Agents / therapeutic use*
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use
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Drug Therapy, Combination / therapeutic use*
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Fever / drug therapy
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Fever / etiology
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Gram-Negative Bacterial Infections / drug therapy*
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Gram-Negative Bacterial Infections / etiology
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Gram-Positive Bacterial Infections / drug therapy*
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Gram-Positive Bacterial Infections / etiology
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Humans
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Imipenem / therapeutic use*
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Mycoplasma Infections / drug therapy*
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Mycoplasma Infections / etiology
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Neoplasms / complications*
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Neoplasms / drug therapy
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Neoplasms / microbiology*
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Neutropenia / chemically induced*
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Neutropenia / drug therapy
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Neutropenia / microbiology*
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Pefloxacin / therapeutic use*
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Thienamycins / therapeutic use*
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Vancomycin / therapeutic use*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antineoplastic Agents
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Thienamycins
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Pefloxacin
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Vancomycin
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Imipenem