Abstract
Ten sesquiterpenoids, including seven new ones, have been isolated from an undescribed sponge of the genus Dysidea. Compounds 1-8 are sesquiterpenoids of the drimane class, while 9 and 10 are 12-norsesquiterpenoids of the same structural class. The structures of novel compounds have been determined by combined spectroscopic methods. These compounds exhibited moderate antimicrobial and enzyme inhibitory (Na+/K(+)-ATPase and PLA2) activities.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Phospholipases A / antagonists & inhibitors
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Phospholipases A2
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Porifera / chemistry*
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
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Spectrophotometry, Ultraviolet
Substances
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Anti-Infective Agents
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Enzyme Inhibitors
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Sesquiterpenes
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Phospholipases A
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Phospholipases A2
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Sodium-Potassium-Exchanging ATPase