Verification of dose and schedule are critical steps in chemotherapy administration. Less than optimal dosing can result in reduced efficacy, and an overdose can cause profound toxicity and death. Use of a systematic format for reviewing chemotherapy orders reduces the potential for medication errors. This systematic approach should include using current weights for dosage calculations, verifying all calculations, obtaining physician clarification when needed, and limiting chemotherapy administration to certified nurses. Patient safety is enhanced by careful verification of chemotherapy dosages and schedules.