Abstract
Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds (O-tocopheryl succinyl O-ethyl ferulate) can increase HIV inhibition. We show here for the first time that O-tocopheryl succinyl O-ethyl ferulate inhibits 80% of HIV replication (HIV-1 acute infection and HIV transmission), inhibits cell lipoperoxidation and prevents cellular glutathione consumption. Compared to ferulate ethyl and tocopheryl succinyl, O-tocopheryl succinyl O-ethyl ferulate inhibits more HIV replication. This may be due in part to the great increase in the lipophilicity of this compound.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Caffeic Acids / pharmacology
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Cell Line
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Cells, Cultured
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Coumaric Acids / pharmacology*
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Glutathione / metabolism
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HIV Core Protein p24 / analysis
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HIV-1 / drug effects
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HIV-1 / physiology*
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Humans
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Lipid Peroxidation / drug effects*
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Macrophages / drug effects
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Macrophages / physiology*
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Macrophages / virology*
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Monocytes / cytology
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Virus Replication / drug effects*
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Vitamin A / analogs & derivatives*
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Vitamin A / pharmacology
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Vitamin E / pharmacology
Substances
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Caffeic Acids
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Coumaric Acids
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HIV Core Protein p24
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O-tocopherylsuccinyl O-ethyl ferulate conjugate
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Vitamin A
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Vitamin E
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ethyl ferulate
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Glutathione