Persistent infection by Helicobacter pylori down-modulates virus-specific CD8+ cytotoxic T cell response and prolongs viral infection

J Infect Dis. 1998 Jan;177(1):72-80. doi: 10.1086/513827.

Abstract

To determine whether Helicobacter pylori infection affects clearance of a concomitant viral infection and cytotoxic T lymphocyte (CTL) and cytokine response to that infection, H. pylori-infected BALB/c mice were challenged with a recombinant vaccinia virus expressing human immunodeficiency virus type 1 gp160. Two H. pylori strains, a colonizing clinical isolate (KS612) and an established standard noncolonizing strain (NCTC11637), were compared. Clearance of recombinant vaccinia virus was reduced in KS612-infected mice compared with NCTC11637-infected and control mice. As a potential mechanism, in contrast to control or NCTC11637-infected mice, the H. pylori clinical isolate KS612 diminished gp160-specific and vaccinia virus-specific CTL activity, even in the presence of exogenous interleukin-2. Furthermore, KS612-infected mice had reduced Th1 cytokine responses to gp120 in vitro compared with control or NCTC11637-infected mice. These results have implications for possible effects of prevalent H. pylori infection on other human diseases.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism
  • Cytotoxicity Tests, Immunologic
  • Female
  • HIV / physiology
  • HIV Envelope Protein gp160 / genetics
  • HIV Envelope Protein gp160 / immunology
  • HIV Infections / complications*
  • HIV Infections / genetics
  • HIV Infections / immunology*
  • Helicobacter Infections / complications*
  • Helicobacter Infections / immunology*
  • Helicobacter pylori / immunology
  • Helicobacter pylori / pathogenicity
  • Interferon-gamma / immunology
  • Interferon-gamma / metabolism
  • Interleukin-2 / immunology
  • Interleukin-2 / metabolism
  • Interleukin-2 / pharmacology
  • Interleukin-4 / immunology
  • Interleukin-4 / metabolism
  • Liver / virology
  • Mice
  • Mice, Inbred BALB C
  • Recombination, Genetic
  • Specific Pathogen-Free Organisms
  • Spleen / immunology
  • Spleen / virology
  • T-Lymphocytes, Cytotoxic / immunology*
  • Vaccinia virus / genetics
  • Virus Latency

Substances

  • Antigens, Bacterial
  • HIV Envelope Protein gp160
  • Interleukin-2
  • Interleukin-4
  • Interferon-gamma