Abstract
A patient with low-grade lymphoma presented 8 months after autologous marrow transplantation with dizziness, aphasia and hemiparesis. Magnetic resonance imaging (MRI) showed an abnormal T2 signal in the frontoparietal region unilaterally. Biopsy of the area demonstrated progressive multifocal leukoencephalopathy positive for JC virus and p53. Treatment with interleukin-2 at 0.5 MU/m2/day i.v. continuous infusion resulted in near complete resolution of symptoms and MRI abnormalities. The absolute number of CD3+CD4+ and CD3-CD56+ cells in the peripheral blood also increased, and the CD4/CD8 ratio normalized. She remains free of evidence of progressive multifocal leukoencephalopathy 1 year off therapy.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Blood Cell Count
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Bone Marrow Transplantation
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DNA, Viral / isolation & purification
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Female
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Humans
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Immunohistochemistry
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Immunophenotyping
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In Situ Hybridization
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Interleukin-2 / therapeutic use*
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JC Virus / isolation & purification*
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Leukoencephalopathy, Progressive Multifocal / diagnosis
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Leukoencephalopathy, Progressive Multifocal / drug therapy*
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Leukoencephalopathy, Progressive Multifocal / etiology*
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Magnetic Resonance Imaging
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Middle Aged
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Papillomavirus Infections / complications*
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Papillomavirus Infections / diagnosis
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Papillomavirus Infections / drug therapy
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Tumor Suppressor Protein p53 / analysis
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Tumor Virus Infections / complications*
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Tumor Virus Infections / diagnosis
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Tumor Virus Infections / drug therapy
Substances
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DNA, Viral
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Interleukin-2
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Tumor Suppressor Protein p53