Abstract
Immunoglobulins (Ig) from healthy, nonimmune individuals bind to the surfaces of Plasmodium falciparum-infected erythrocytes (RBC). In order to investigate the presence of this parasite phenotype in wild isolates and its potential association with malarial anemia, we conducted a study of 207 anemic or nonanemic children with malaria in Gabon. Surface Ig binding to infected RBC was detected for 83% of the isolates. No difference in Ig binding between the groups was observed, but all isolates which exhibited extensive Ig binding were found in a group of moderately anemic children.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Anemia / complications*
-
Anemia / epidemiology
-
Anemia / etiology
-
Child
-
Child, Preschool
-
Erythrocytes / immunology*
-
Erythrocytes / parasitology*
-
Gabon / epidemiology
-
Humans
-
Immunoglobulin G / analysis
-
Immunoglobulin G / immunology
-
Immunoglobulin M / analysis
-
Immunoglobulin M / immunology
-
Immunoglobulins / analysis
-
Immunoglobulins / immunology*
-
Infant
-
Malaria, Falciparum / complications*
-
Malaria, Falciparum / epidemiology
-
Malaria, Falciparum / immunology*
-
Rosette Formation
Substances
-
Immunoglobulin G
-
Immunoglobulin M
-
Immunoglobulins